Synthetic Cannabinoids (K2/Spice)

Synthetic Cannabinoids (K2/Spice)

Synthetic cannabinoids are human-made mind-altering chemicals that are either sprayed on dried, shredded plant material so they can be smoked or sold as liquids to be vaporized and inhaled in e-cigarettes and other devices. These products are also known as herbal or liquid incense. Learn about the health effects of synthetic cannabinoids and read the DrugFacts.

Manufacturers sell these products in colorful foil packages and plastic bottles to attract consumers. They market these products under a wide variety of specific brand names. 

For several years, synthetic cannabinoid mixtures have been easy to buy in drug paraphernalia shops, novelty stores, gas stations, and over the internet. Because the chemicals used in them have no medical benefit and a high potential for abuse, authorities have made it illegal to sell, buy, or possess some of these chemicals. However, manufacturers try to sidestep these laws by changing the chemical formulas in their mixtures.

Easy access and the belief that synthetic cannabinoid products are natural and therefore harmless, have likely contributed to their use among young people. Another reason for their continued use is that standard drug tests cannot easily detect many of the chemicals used in these products.

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How do people use synthetic cannabinoids?

The most common way to use synthetic cannabinoids is to smoke the dried plant material. Users also mix the sprayed plant material with marijuana or brew it as tea. Other users buy synthetic cannabinoid products as liquids to vaporize in e-cigarettes.

How do synthetic cannabinoids affect the brain?

Synthetic cannabinoids act on the same brain cell receptors as THC (delta-9-tetrahydrocannabinol), the mind-altering ingredient in marijuana.

So far, there have been few scientific studies of the effects of synthetic cannabinoids on the human brain, but researchers do know that some of them bind more strongly than marijuana to the cell receptors affected by THC and can produce much stronger effects. The resulting health effects can be unpredictable and dangerous.

Because the chemical composition of many synthetic cannabinoid products is unknown and may change from batch to batch, these products are likely to contain substances that cause dramatically different effects than the user might expect.

Synthetic cannabinoid users report some effects similar to those produced by marijuana:

  • elevated mood
  • relaxation
  • altered perception—awareness of surrounding objects and conditions
  • symptoms of psychosis—delusional or disordered thinking detached from reality

Psychotic effects include:

  • extreme anxiety
  • confusion
  • paranoia—extreme and unreasonable distrust of others
  • hallucinations—sensations and images that seem real though they are not

What are some other health effects of synthetic cannabinoids?

People who have used synthetic cannabinoids and have been taken to emergency rooms have shown severe effects including:

  • rapid heart rate
  • vomiting
  • violent behavior
  • suicidal thoughts

Are synthetic cannabinoids addictive?

Yes, synthetic cannabinoids can be addictive. Regular users trying to quit may have the following withdrawal symptoms:

  • headaches
  • anxiety
  • depression
  • irritability

Behavioral therapies and medications have not specifically been tested for treatment of addiction to these products. Health care providers should screen patients for possible co-occurring mental health conditions.

Can you overdose on synthetic cannabinoids?

Yes. An overdose occurs when a person uses too much of a drug and has a dangerous reaction that results in serious, harmful symptoms or death. Use of synthetic cannabinoids can cause:

  • toxic reactions
  • elevated blood pressure
  • reduced blood supply to the heart
  • kidney damage
  • seizures

Deaths can also occur when dangerous synthetic opioids, such as fentanyl, are added to the packaged mixture without the user knowing it.

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